HIPAA and Advanced Scientific Computing

Demand for compute cycles and massive data storage has been growing rapidly in biomedical research. Activities on topics such as electronic health record analytics and gene sequencing are placing an increasing burden on academic medical college IT departments with limited ability to scale. As a result, campus and national advanced scientific computing centers (ASCCs) are being asked to accommodate biomedical researchers. This presents a challenge to these organizations since clinical research data or electronic health records contain identifiable patient information protected by the federal Privacy and Security Rules promulgated under the Health Insurance Portability and Accountability Act (HIPAA) of 1996. The HIPAA Privacy and Security Rules require entities to protect the privacy of individually identifiable health information or protected health information (PHI). The rules specify the types of safeguards that must be put in place including required security controls to ensure patient privacy

Socio-Economic Characteristics of Gram Panchayat Members at Hanumanganj Block of Ballia District of Uttar Pradesh

Introduction of Panchayat Raj was hailed as one of the most important political innovations in Independent India. It was also considered as a revolutionary step. Panchayat Raj is a system of local self-government wherein the people take upon themselves the responsibility for development. The Gram Panchayat has occupied an important place in taking people’s political, economic, social, patriotic aspirations and emotions to the government in order to build a strongest nation ever. The study was based on both Primary and Secondary data. Descriptive research design has been used in the present study. The study revealed that majority of respondents were middle age people, having education up to junior high school and mostly dependent on farming for their income. A large sum of the respondents had very high annual income while few of the respondents had low annual income. It is concluded that the majority of the respondents belonged to the middle socio-economic status. Social participation of Gram Panchayat members were significant in Gram Panchayat activities. Majority of respondents daily use newspaper as a means of mass media exposure. View Article DOI: 10.47856/ijaast.2021.v08i4.00

The medical science DMZ: a network design pattern for data-intensive medical science

Abstract: Objective We describe a detailed solution for maintaining high-capacity, data-intensive network flows (eg, 10, 40, 100 Gbps+) in a scientific, medical context while still adhering to security and privacy laws and regulations. Materials and Methods High-end networking, packet-filter firewalls, network intrusion-detection systems. Results We describe a “Medical Science DMZ” concept as an option for secure, high-volume transport of large, sensitive datasets between research institutions over national research networks, and give 3 detailed descriptions of implemented Medical Science DMZs. Discussion The exponentially increasing amounts of “omics” data, high-quality imaging, and other rapidly growing clinical datasets have resulted in the rise of biomedical research “Big Data.” The storage, analysis, and network resources required to process these data and integrate them into patient diagnoses and treatments have grown to scales that strain the capabilities of academic health centers. Some data are not generated locally and cannot be sustained locally, and shared data repositories such as those provided by the National Library of Medicine, the National Cancer Institute, and international partners such as the European Bioinformatics Institute are rapidly growing. The ability to store and compute using these data must therefore be addressed by a combination of local, national, and industry resources that exchange large datasets. Maintaining data-intensive flows that comply with the Health Insurance Portability and Accountability Act (HIPAA) and other regulations presents a new challenge for biomedical research. We describe a strategy that marries performance and security by borrowing from and redefining the concept of a Science DMZ, a framework that is used in physical sciences and engineering research to manage high-capacity data flows. Conclusion By implementing a Medical Science DMZ architecture, biomedical researchers can leverage the scale provided by high-performance computer and cloud storage facilities and national high-speed research networks while preserving privacy and meeting regulatory requirements

University Information Technology Services' Advanced IT Facilities: The least every researcher needs to know

This is an archived document containing instructions for using IU's advanced IT facilities ca. 2003. A version of this document updated in 2011 is available from http://hdl.handle.net/2022/13620. Further versions are forthcoming.This document is designed to be read as a printed document, and designed to permit anyone at all familiar with computers and the Internet to start at the beginning, get a general overview of UITS' advanced IT facilities and what they offer, and then read the detailed portions of the document that are of interest. In many cases, examples are provided, as well as directions on how to download sample files. And in some cases there is information that one is best off really not learning – for example the process of logging into IU's IBM supercomputer the first time involves setup steps that should be followed, keystroke by keystroke, from the directions presented herein, and then promptly forgotten. This document is intended to be a starting point, not a comprehensive guide. As such it should get any reader off to a good start, but then point the reader in the direction of consulting staff and online resources that will permit the reader to get additional help and information as needed. Most of all, this document is provided for the convenience of researchers, who may peruse this information at their leisure. Our hope and expectation is that consultants in UITS will provide extensive help and programming assistance to IU researchers who wish to make use of these excellent IT facilities.The facilities described in this document were made possible in part through funding from Indiana University, the Indiana University Office of the Vice President for Information Technology, the State of Indiana, Shared University Research Grants from IBM, Inc., the National Science Foundation under Grant No. 0116050 and Grant CDA- 9601632, and from the Lilly Endowment through their support of the Indiana Genomics Initiative. The Indiana Genomics Initiative (INGEN) of Indiana University is supported in part by Lilly Endowment Inc

INGEN's advanced IT facilities: The least you need to know

The facilities described in this document were made possible in part through funding from Indiana University, the Indiana University Office of the Vice President for Information Technology, the State of Indiana, Shared University Research Grants from IBM, Inc., and from the Lilly Endowment through their support o f the Indiana Genomics Initiative. The Indiana Genomics Initiative (INGEN) of Indiana University is supported in part by Lilly Endowment Inc

2003 Report on Indiana University Accomplishments supported by Shared University Research Grants from IBM, Inc.

Indiana University and IBM, Inc. have a very strong history of collaborative research, aided significantly by Shared University Research (SUR) grants from IBM to Indiana University. The purpose of this document is to review progress against recent SUR grants to Indiana University. These grants focus on the joint interests of IBM, Inc. and Indiana University in the areas of deep computing, grid computing, and especially computing for the life sciences. SUR funding and significant funding from other sources, including a $1.8M grant from the NSF and a portion of a$105M grant to Indiana University to create the Indiana Genomics Initiative, have enabled Indiana University to achieve a suite of accomplishments that exceed the ambitious goals set out in these recent SUR grants

Indiana University's Advanced Cyberinfrastructure

This is an archived document. The most current version may be found at http://pti.iu.edu/ciThe purpose of this document is to introduce researchers to Indiana University’s cyberinfrastructure – to clarify what these facilities make possible, to discuss how to use them and the professional staff available to work with you. The resources described here are complex and varied, among the most advanced in the world. The intended audience is anyone unfamiliar with IU’s cyberinfrastructure

In Vivo Toxicity Study of Ethanolic Extracts of Evolvulus alsinoides & Centella asiatica in Swiss Albino Mice

AIM: We aimed to investigate several parameters after the in vivo acute and sub-acute administration of ethanolic extracts from E. alsinoides & C. asiatica. METHODS: Malignant Ovarian Germ Cell Tumors for in vivo toxicity study guidelines 423 and 407 of Organization for Economic Co-operation and Development (OECD) were followed for acute and sub-acute toxicity assays respectively. For LD50 evaluation, a single dose of ethanolic extracts of Evolvulus alsinoides L. (EEA) and ethanolic extracts of Centella asiatica (ECA) was orally administered to mice at doses of 200, 400, 800, 1600 and 2000 mg/kg. Then the animals were observed for 72 hours. For acute toxicity evaluation, a single dose of both extracts was orally administered to mice at doses of 300, 600, 1200 and 2000 mg/kg and the animals were observed for 14 days. In the sub-acute study, the extracts were orally administered to mice for 28 days at doses of 300, 600, 1200 and 2000 mg/kg. To assess the toxicological effects, animals were closely observed on general behaviour, clinical signs of toxicity, body weight, food and water intake. At the end of the study, it was performed biochemical and hematological evaluations, as well as histopathological analysis from the following organs: brain, heart, liver, and kidney. RESULTS: The oral administration of E. alsinoides and C. asiatica ethanolic extracts, i.e. EEA 300, EEA 600, EEA 1200, EEA 2000, ECA 300, ECA 600, ECA 1200 & ECA 2000 mg/kg doses showed no moral toxicity effect in LD50, acute and sub-acute toxicity parameters. CONCLUSION: In this study, we had found that E. alsinoides & C. asiatica extract at different doses cause no mortality in acute and sub-acute toxicity study. Also, histopathology of kidney, liver, heart, and brain showed no alterations in tissues morphology

Neuroprotective Activity of Evolvulus alsinoides & Centella asiatica Ethanolic Extracts in Scopolamine-Induced Amnesia in Swiss Albino Mice

AIM: To carry out the comparative nootropic, neuroprotective potentials of two medicinal plant species. MATERIAL AND METHODS: For neuroprotective activity; behavior models (elevated plus maze & morris water maze), in vivo antioxidant (superoxide dismutase, catalase, lipid peroxidation & reduced glutathione), inflammatory markers (IL-1β, IL-6 & TNF-α) and acetylcholine esterase (AChE) assessment procedures followed at different dosages i.e. 250 & 500 mg/kg of Evolvulus alsinoides and Centella asiatica ethanolic extracts. At the end of the study, it was performed histopathological analysis of the following organs: brain, heart, liver, and kidney. RESULTS: In oral administration of different doses of ethanolic extracts of both medicinal plants i.e. Sco + EEA 250 = 2.49 ± 0.29 , Sco + EEA 500 = 2.67 ± 0.36, Sco + ECA 250 = 2.33 ± 0.17, Sco + ECA 500 = 2.77 ± 0.21, Sco + EEA + ECA 250 = 2.61 ± 0.32 and Sco + EEA + ECA 500 = 2.79 ± 0.16 U/mg of protein respectively against the scopolamine induced group Sco (control) = 5.51 ± 0.35 U/mg of protein extracts shows neuroprotective and nootropic activity with reducing AChE level in the brain homogenate of swiss albino mice. CONCLUSION: Since the E. alsinoides & C. asiatica are already used in traditional Indian medicine as the neuroprotective agent and also found promising effects over inflammatory diseases, wound healing, and immunomodulatory activity. The neuroprotective effect of both plants extracts attributed to inhibition of AChE activity and improve the spatial memory formation